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Growth hormone-induced blood pressure decrease is associated with increased mRNA levels of the vascular smooth muscle
Asa Tivesten1, Anna Barlind, Kenneth Caidahl
1Research Center for Endocrinology and Metabolism, Department of Internal Medicine, Sahlgrenska University Hospital, S-413 45 Göteborg, Sweden. asa.tivesten@medic.gu.se
The Journal of Endocrinology
|November 5, 2004
Summary
Growth hormone (GH) treatment improves vascular function by reducing blood pressure and enhancing blood flow. GH up-regulates key genes in vascular smooth muscle, suggesting a novel mechanism for regulating blood vessel tone.
Area of Science:
- Endocrinology
- Vascular Physiology
- Molecular Biology
Background:
- Growth hormone (GH) deficiency is linked to vascular dysfunction and atherosclerosis.
- GH replacement therapy can improve vascular health, but underlying molecular mechanisms are unclear.
Purpose of the Study:
- To investigate the molecular mechanisms by which GH influences vascular physiology.
- To identify GH-regulated genes impacting vascular tone and atherogenesis.
Main Methods:
- Hypophysectomized male Sprague Dawley rats were treated with GH or saline.
- Vascular parameters (blood pressure, cardiac output) were assessed.
- Aortic mRNA expression was analyzed using microarray technology.
Main Results:
- GH treatment reduced systolic blood pressure and systemic vascular resistance.
- GH increased cardiac output.
- 18 GH-regulated genes were identified, including Kir6.1 and sulfonylurea receptor 2B, components of the vascular smooth muscle ATP-sensitive potassium channel.
Conclusions:
- GH plays a significant role in regulating vascular physiology and gene expression.
- Upregulation of the ATP-sensitive potassium channel by GH is a potential mechanism for controlling vascular tone.