Related Experiment Video

Updated: Aug 21, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
09:37

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

Biological functions of the ING family tumor suppressors

E I Campos1, M Y Chin, W H Kuo

  • 1Department of Medicine, Division of Dermatology, University of British Columbia, V6H 3Z6, Vancouver, British Columbia, Canada.

Cellular and Molecular Life Sciences : CMLS
|November 5, 2004
PubMed

Insights

The inhibitor of growth 1 (ING1) gene and related ING proteins are crucial tumor suppressors involved in apoptosis, senescence, and DNA repair. This review summarizes their biological functions and signaling pathways.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • The inhibitor of growth 1 (ING1) gene is the first identified member of the ING tumor suppressor family.
  • ING1 and related genes are implicated in critical cellular processes like apoptosis and senescence.
  • Dysregulation of these genes contributes to tumor development.

Purpose of the Study:

  • To review the known biological functions of ING tumor suppressors.
  • To summarize the signaling pathways regulated by ING proteins.
  • To highlight the role of ING proteins in cancer.

Main Methods:

  • Literature review of early and recent studies on ING genes.
  • Analysis of biochemical functions of ING proteins.
  • Summary of findings on ING proteins' roles in cellular processes.

Main Results:

  • ING genes are involved in apoptosis, cellular senescence, cell cycle arrest, and DNA repair.
  • ING proteins function as histone acetyltransferases and histone deacetylase co-factors.
  • These functions link ING proteins to the regulation of gene transcription and cell cycle checkpoints.

Conclusions:

  • The ING tumor suppressor family plays a significant role in maintaining genomic stability and preventing cancer.
  • Understanding ING protein functions provides insights into novel therapeutic strategies for cancer treatment.

More Related Videos

Knockdown of FAM83A to Verify Its Role in Cervical Cancer Cell Growth and Cisplatin Sensitivity04:20

Knockdown of FAM83A to Verify Its Role in Cervical Cancer Cell Growth and Cisplatin Sensitivity

Published on: February 9, 2024

Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia08:14

Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia

Published on: July 25, 2017

Related Concept Videos

Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...