Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inflammatory activity in river-water samples.

G Wichmann1, C Daegelmann, O Herbarth

  • 1Department of Environmental Immunology, UFZ Centre for Environmental Research Leipzig--Halle Ltd., Leipzig, Germany. gunnar.wichmann@ufz.de

Environmental Toxicology
|November 5, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A simple clinical risk score can predict frailty in HNSCC patients.

Cancer treatment and research communications·2026
Same author

A multiomic framework for predicting laryngo-esophageal dysfunction following induction chemotherapy in hypopharyngeal-laryngeal carcinoma.

ESMO open·2025
Same author

Estrogenic, Genotoxic, and Antibacterial Effects of Chemicals from Cryogenically Milled Tire Tread.

Environmental toxicology and chemistry·2024
Same author

Evaluation of tire tread particle toxicity to fish using rainbow trout cell lines.

The Science of the total environment·2023
Same author

The Light-Dosimeter: A new device to help advance research on the non-visual responses to light.

Lighting research & technology (London, England : 2001)·2023
Same author

Association between malformation type, location and functional deficits in lymphatic malformations of the head and neck in children.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2023
Same journal

Ecotoxicological Assessment of Mercury in Fish From a Gold-Mining-Impacted Amazonian River: Biomonitoring and Human Health Risk.

Environmental toxicology·2026
Same journal

Artemia salina Toxicity Assay: Standardization in a 24-Well Microplate.

Environmental toxicology·2026
Same journal

Nanoceria Provokes Apoptosis in Different Critical Organs of Mus musculus.

Environmental toxicology·2026
Same journal

Acute Exposure to Environmentally Relevant Concentrations of Ciprofloxacin and Levonadifloxacin Alters Behavior, Organ Health, and Stress Response in Adult Zebrafish.

Environmental toxicology·2026
Same journal

EXPRESSION OF CONCERN: "Up-Regulation of Gadd45α After Exposure to Metal Nanoparticles: The Role of Hypoxia Inducible Factor 1α".

Environmental toxicology·2026
Same journal

Relative Toxicity and Risk Assessment of Commonly Used Insecticides for the Management of Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae).

Environmental toxicology·2026
See all related articles

Urban river water contamination by endotoxins triggers inflammatory responses in human immune cells. This highlights the need for monitoring microbial contaminants in aquatic environments to protect ecosystem and human health.

Area of Science:

  • Environmental Science
  • Immunology
  • Public Health

Background:

  • Urban aquatic environments face contamination from chemical and biological substances.
  • This contamination threatens ecosystem integrity and water quality for human use.
  • Assessing immunological impacts is crucial for understanding health risks.

Purpose of the Study:

  • To evaluate the immunological effects of River Saale water samples.
  • To identify specific contaminants responsible for observed immune responses.
  • To assess the role of endotoxins in water-induced inflammation.

Main Methods:

  • Peripheral blood mononuclear cells (PBMC) from healthy donors were cultured with river and drinking water.
  • Cell vitality was measured using the MTT bioassay.

Related Experiment Videos

  • Cytokine secretion (TNF-alpha, IL-1beta, IL-6) and endotoxin levels (LAL test) were quantified.

    • Main Results:

    • River water showed minimal cytotoxic effects but induced proinflammatory cytokine secretion.
    • Endotoxins were detected in all river water samples, with highest levels downstream of a wastewater treatment plant.
    • Inhibition studies confirmed endotoxin as the primary driver of cytokine induction.

    Conclusions:

    • Microorganism-derived endotoxin is a significant contaminant in urban aquatic environments.
    • Endotoxin exposure can trigger inflammatory immune responses.
    • Routine monitoring of endotoxins is recommended for ecosystem and human health assessment.