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Updated: Jul 30, 2026
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Restenosis in the coronary stent is an argument for the surgical myocardial revascularization
Insights
Coronary artery bypass grafting (CABG) showed a lower restenosis rate than percutaneous coronary intervention (PCI) using stents in patients with multivessel coronary disease. This finding is notable as drug-eluting stents were not widely used in this study.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Cardiac Surgery
Background:
- Coronary artery disease (CAD) management often involves revascularization procedures.
- Percutaneous coronary intervention (PCI) with stents and Coronary Artery Bypass Grafting (CABG) are primary treatment options.
- Evaluating restenosis rates is crucial for long-term patient outcomes.
Purpose of the Study:
- To compare the frequency of restenosis between PCI (stents) and CABG.
- To assess restenosis rates based on clinical criteria (angina recurrence).
- To provide insights into the effectiveness of different revascularization strategies.
Main Methods:
- Retrospective analysis of 6564 coronarographies (1999-2002).
- Included 3110 patients undergoing myocardial revascularization (PCI or CABG).
- Angiographic follow-up was performed on 105 patients (55 PCI, 50 CABG) based on clinical recurrence of angina.
Main Results:
- Restenosis occurred in 47 patients (74.5%) treated with stents and 29 patients after CABG.
- The overall restenosis rate was 4.8% for PCI and 2.5% for CABG.
- CABG demonstrated a lower restenosis rate compared to PCI in this cohort.
Conclusions:
- Both CABG and PCI are effective for multivessel coronary disease.
- CABG showed a lower restenosis rate than PCI, particularly in the absence of widespread drug-eluting stent (DES) use.
- The advent of DES may alter restenosis rates in PCI, highlighting a complex interplay of factors in restenosis prevention.
Background:
This study will evaluate the difference between the frequency of restenosis in myocardial revascularization procedures by stents and CABG by coronarographic control after clinical criteria (angina).
Methods And Results:
Out of the total of 6564 coronarographies performed (1999-2002) for diagnosis purposes, 3110 patients (44.8%) underwent myocardial revascularization procedures, PCI or CABG. PCI was performed in 981 patients (31%) and CABG in 1148 patients (37.3%). At the same time, we performed in our units 2067 surgical procedures, out of which 1148 (55%) revascularizations by CABG. The angiographic control for patients with myocardial revascularization by stent (55 patients) or CABG (50 patients) was performed by clinical criteria (angina reappears) on 105 patients. The restenosis we found in 47 patients (74.5%) treated by stent revascularization and in 29 patients from CABG procedures. In our study restenosis rate was 4.8% in patients with PCI and 2.5% in patients with CABG.
Conclusions:
Both surgical (CABG) and percutaneous coronary artery revascularization (PCI) have proved to be extremely effective in the treatment of patients with multivessel coronary disease. In our study restenosis rate was smaller in the patients with CABG than in the PCI group, taking into account the fact that we did not use drug eluting stent (DES) on a large scale. Results from the series of randomized trials (SOS, SIRIUS, ERACI, ARTS, BARI, etc.) have shown that the restenosis phenomenon is an apparent advantage in patients with DES. Restenosis prevention is a complex phenomenon (inflammation, procoagulation, cellular migration, etc.) and DES appearance opens a new era in PCI.
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