Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The response to beta-agonists in wheezy infants: three methods compared.

Caroline S Beardsmore1, Catherine Page, Michael Silverman

  • 1Department of Child Health, Institute for Lung Health, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, P.O. Box 65, Leicester LE2 7LX, UK. csb@le.ac.uk

Respiratory Medicine
|November 6, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safety of antibiotic audit and feedback: secondary analysis of a randomized controlled trial.

The Journal of antimicrobial chemotherapy·2026
Same author

Impact of masking policy on healthcare-associated acute respiratory infections in 18 hospitals in Southern Ontario.

Antimicrobial stewardship & healthcare epidemiology : ASHE·2026
Same author

Appropriateness and determinants of outpatient antibiotic use among migrants in British Columbia, Canada: a population-based study.

JAC-antimicrobial resistance·2026
Same author

Extended-duration dexamethasone for the treatment of hospitalized COVID-19 patients in Canada: A randomized clinical trial.

Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada·2026
Same author

Music therapy interest in patients with Alzheimer's disease and Alzheimer's disease related dementia: A survey study.

Journal of Alzheimer's disease : JAD·2026
Same author

Exploring the Influence of Testosterone on Pain Perception and Modulation Among Men with Low and Normal Testosterone Concentrations.

Journal of pain research·2026
Same journal

Targeting the neutrophil-DPP-1-protease axis in airway disease: current evidence and future indications.

Respiratory medicine·2026
Same journal

The lung microbiome in hematopoietic stem cell transplantation: immune interactions, clinical consequences, and emerging interventions.

Respiratory medicine·2026
Same journal

GLP-1 receptor agonists in obstructive sleep apnea: A propensity score-matched real-world analysis.

Respiratory medicine·2026
Same journal

The Hidden Burden of Overlap Syndrome: Sleep Quality and Functional Impairment in Chronic Obstructive Pulmonary Disease.

Respiratory medicine·2026
Same journal

Quantitative CT-Derived Extrapulmonary Body Composition and the Risk of Acute Exacerbations in COPD: A Prospective Cohort Study.

Respiratory medicine·2026
Same journal

Characteristics of Patients with Acute Respiratory Failure in Obesity Hypoventilation Syndrome in the Intensive Care Unit: A Retrospective Cohort Study.

Respiratory medicine·2026
See all related articles

Salbutamol did not consistently improve wheezing in infants when assessed by forced expiration. Respiratory mechanics measures showed no significant changes, suggesting alternative assessment methods may be better.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Physiology

Background:

  • Conflicting results exist regarding salbutamol's effectiveness for infantile wheeze.
  • Differences in outcome variables may explain inconsistent findings.

Purpose of the Study:

  • To evaluate salbutamol's effect on infantile wheeze using passive and forced expiration indices.
  • To assess bronchodilator response in infants with wheezing history.

Main Methods:

  • Recruited 39 infants with wheezing history (mean age 43 weeks).
  • Measured maximal flow at functional residual capacity (V'(max FRC)) and forced expired volume at 0.4s (FEV0.4).
  • Assessed passive compliance (C(rs)), resistance (R(rs)), and time constant (tau) before and after salbutamol inhalation.

Main Results:

Related Experiment Videos

  • No significant mean changes in forced expiration indices (V'(max FRC), FEV0.4) post-salbutamol.
  • Some infants showed individual improvements or worsening in specific indices.
  • A small increase in passive compliance (C(rs)) was observed, but resistance (R(rs)) and time constant (tau) remained unchanged.

Conclusions:

  • No consistent bronchodilator response to salbutamol was observed in forced expiration indices.
  • Respiratory mechanics may not be the most reliable method for assessing salbutamol response in this population.
  • Validated clinical scores or alternative physiological techniques are recommended for evaluating bronchodilator response.