[Changes in selected parameters of bone turnover resulting from use of different calcium concentrations in dialysate...

Renal osteodystrophy is a common complication occurring in patients with end stage disease. Using dialysis solutions with different concentrations of calcium undoubtedly has an influence on calcium-phosphorus homeostasis and bone turnover. The aim of the study was to examine the influence of dialysate with calcium concentrations of Ca 1.75 mmol/l and Ca 1.25 mmol/l on selected parameters of bone turnover. The study was performed on 12 clinically stable patients treated with CAPD. After 24 weeks of the treatment with Ca 1.75 mmol/l solution the initial investigation was performed. The next step was to switch to dialysate with the Ca level of 1.25 mmol/V. After 2, 12, and 24 weeks of the treatment with solutions of low calcium level the concentrations of PTH, osteocalcin, total calcium, and ionized calcium, phosphorus were calculated. We have observed that the level of PTH and osteocalcin was increased significantly at the time of treatment with Ca 1.25 mmol/l solution. We have also observed a decrease in concentration of total and ionized calcium. We did not observe any change of phosphorus concentrations in the serum of treated patients.