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Waldenstrom's macroglobulinemia presenting as Goodpasture's syndrome
Sonia Gandhi1, Mark A Little, Ken Farrington
1Renal Section, Division of Medicine, Imperial College, Hammersmith Hospital, London, UK.
Abstract:
We report a case of Waldenstrom's macroglobulinemia (WM) presenting as classic Goodpasture's syndrome. Thrombocytopenia, an additional autoimmune phenomenon, further complicated the clinical course. Renal disease is well recognized in Waldenstrom's macroglobulinemia and other B-cell dyscrasias. Similarly, a wide spectrum of autoimmune-mediated conditions has been reported in association with paraproteinemia. However, rapidly progressive glomerulonephritis in association with antiglomerular basement membrane antibodies has never been reported as either an autoimmune or a renal manifestation of WM. This article reviews the current understanding of renal pathology and autoimmune phenomenon associated with WM.
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