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FSH time-concentration profiles before and after administration of 0.25 mg cetrorelix in the gnRH-antagonist
G Griesinger1, D Finas, A Alisch
1Department of Obstetrics and Gynecology, Medical University of Schleswig-Holstein, Campus Luebeck, 23538 Luebeck, Germany. georg.griesinger@frauenklinik.uni-luebeck.de
Purpose:
To determine FSH concentration behavior before and after cetrorelix 0.25 mg administration in the GnRH-antagonist multiple-dose protocol on day 6 of ovarian stimulation with 150-300 IU daily recombinant FSH.
Methods:
Blood samples for FSH measurements were drawn from seven women every 15 min from 8 h prior to the first cetrorelix administration in the GnRH-antagonist multiple-dose protocol until 15-32 h thereafter.
Results:
No significant change of FSH concentration was observed.
Conclusions:
This observation indicates that no rationale exists of increasing the daily FSH dosage concomitantly to the GnRH-antagonist administration to compensate for a drop of endogenous FSH.
