Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lithium ion "cyclotron resonance" magnetic fields decrease seizure onset times in lithium-pilocarpine seized rats.

B E McKay1, M A Persinger

  • 1Behavioral Neuroscience Laboratory, Laurentian University, Sudbury, Ontario, Canada.

The International Journal of Neuroscience
|November 6, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increased photon emission from the head while imagining light in the dark is correlated with changes in electroencephalographic power: support for Bókkon's biophoton hypothesis.

Neuroscience letters·2012
Same author

Correlated cerebral events between physically and sensory isolated pairs of subjects exposed to yoked circumcerebral magnetic fields.

Neuroscience letters·2010
Same author

10-20 Joules as a neuromolecular quantum in medicinal chemistry: an alternative approach to myriad molecular pathways?

Current medicinal chemistry·2010
Same author

Emerging synergisms between drugs and physiologically-patterned weak magnetic fields: implications for neuropharmacology and the human population in the twenty-first century.

Current neuropharmacology·2009
Same author

Prenatal exposures to LTP-patterned magnetic fields: quantitative effects on specific limbic structures and acquisition of contextually conditioned fear.

The International journal of neuroscience·2009
Same author

Insidious weight gain in prepubertal seized rats treated with an atypical neuroleptic: the role of food consumption, fluid consumption, and spontaneous ambulatory activity.

Epilepsy & behavior : E&B·2008
Same journal

A Predictive Model for Early Neurological Deterioration in Medullary Infarction Based on Explainable Machine Learning.

The International journal of neuroscience·2026
Same journal

Thoracic paravertebral nerve block combined with general anesthesia for patients undergoing minimally invasive vertebroplasty: effects on pain and lumbar function.

The International journal of neuroscience·2026
Same journal

Recurrence associated IGFBP2 promotes malignant progression and epithelial mesenchymal transition in glioma cells via the AKT mTOR pathway.

The International journal of neuroscience·2026
Same journal

Decreased miR-1305 expression is associated with tumour invasiveness and poor prognosis in glioma patients.

The International journal of neuroscience·2026
Same journal

Astaxanthin alleviates ischemia-reperfusion injury by regulating the JAK2/STAT3 signaling pathway.

The International journal of neuroscience·2026
Same journal

Clinical efficacy of cryopreserved autologous bone flaps versus titanium plates for cranioplasty: a retrospective comparative study.

The International journal of neuroscience·2026
See all related articles

This study explored how magnetic fields affect lithium ion activity in rats. Specific magnetic field intensities, based on cyclotron resonance, influenced seizure onset times, suggesting targeted windows for ion interaction.

Area of Science:

  • Biophysics
  • Neuropharmacology
  • Ion Physics

Background:

  • The cyclotron resonance equation relates magnetic field frequency to ion properties.
  • Understanding ion-specific magnetic field interactions is crucial for potential therapeutic applications.
  • Lithium's effects on seizure onset time (SOT) are dose-dependent.

Purpose of the Study:

  • To investigate the applicability of the cyclotron resonance equation for optimizing lithium ion utilization in rats.
  • To determine if magnetic fields can induce a shift in lithium's dose-dependent SOT curve when combined with pilocarpine.
  • To identify potential intensity windows for magnetic field effects on ion activity.

Main Methods:

  • Rats were administered varying doses of lithium chloride.

Related Experiment Videos

  • Animals were exposed to a 85 Hz magnetic field at different intensities (70 nT, 0.8 µT, 25 µT) or reference conditions.
  • Seizure onset times (SOTs) were recorded in conjunction with pilocarpine administration.

    • Main Results:

    • A significant U-shaped quadratic relationship was observed between magnetic field intensity and SOT, irrespective of lithium dose.
    • Equal SOTs were noted for reference and 25 µT groups.
    • A trend towards shorter SOTs was observed at 70 nT and 0.8 µT magnetic field intensities.

    Conclusions:

    • The study suggests discrete intensity windows exist where magnetic field frequencies, derived from cyclotron ion resonance principles, can influence ion activity.
    • Observed effects on SOT were not fully predicted by the initial cyclotron resonance equation, indicating a more complex interaction.
    • Findings support further research into targeted magnetic field applications for modulating ion behavior in biological systems.