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Elevated serum parathormone after Roux-en-Y gastric bypass
Maria de Fátima Haueisen Sander Diniz1, Marco Túlio Costa Diniz, Soraya Rodrigues Almeida Sanches
1Serviço de Endocrinologia e Metabologia, Hospital das Clínicas da Universidade Federal de Minas Gerais, Av Alfredo Balena, 30130-100 Belo Horizonte, Minas Gerais, Brazil. mfhsdiniz@ufmg.br
Obesity Surgery
|November 6, 2004
Summary
Roux-en-Y gastric bypass (RYGBP) can lead to early bone metabolism changes. Routine monitoring and calcium replacement are recommended post-surgery to prevent potential bone disease.
Area of Science:
- Endocrinology
- Gastroenterology
- Metabolic Surgery
Background:
- Gastric bypass surgery can disrupt calcium and vitamin D metabolism early on.
- Clinical signs of metabolic bone disease may appear years after bariatric procedures.
- Early detection of metabolic changes is crucial for long-term patient health.
Purpose of the Study:
- To assess the impact of bariatric surgery on bone metabolism.
- To evaluate postoperative changes in key biochemical markers.
- To identify early indicators of bone health alterations post-RYGBP.
Main Methods:
- Prospective follow-up of 110 patients undergoing Roux-en-Y gastric bypass (RYGBP).
- Measurement of intact parathormone (PTHi), alkaline phosphatase, ionic calcium, phosphorus, and magnesium levels.
- Utilized chemiluminescence and colorimetric methods for biochemical analyses.
Main Results:
- Elevated serum PTHi levels were detected in 29% of patients.
- Hypocalcemia was observed in 0.9% of patients.
- Abnormalities were noted from 3 to 80 months post-surgery.
Conclusions:
- Bariatric surgery necessitates careful monitoring of bone metabolism.
- Routine calcium supplementation is advised after RYGBP.
- Early biochemical screening can help manage bone health post-surgery.