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Updated: Aug 21, 2026

Roux-en-Y Gastric Bypass Operation in Rats
Published on: June 11, 2012
Elevated serum parathormone after Roux-en-Y gastric bypass
Maria de Fátima Haueisen Sander Diniz1, Marco Túlio Costa Diniz, Soraya Rodrigues Almeida Sanches
1Serviço de Endocrinologia e Metabologia, Hospital das Clínicas da Universidade Federal de Minas Gerais, Av Alfredo Balena, 30130-100 Belo Horizonte, Minas Gerais, Brazil. mfhsdiniz@ufmg.br
Background:
Abnormalities in calcium and vitamin D metabolism are observed early after gastric bypass, whereas clinical or biochemical evidence of metabolic bone disease might not be detected until many years after the procedure. The aim of the present study was to evaluate the impact of bariatric surgery on bone metabolism determined on the basis of postoperative laboratory changes in calcium, phosphorus, magnesium, alkaline phosphatase and parathormone (PTH) levels.
Methods:
110 patients submitted to Roux-en-Y gastric bypass (RYGBP) were followed after surgery, and the following parameters were determined: intact PTH molecule (PTHi; chemiluminescence), alkaline phosphatase (colorimetric method), ionic calcium (selective electrode), phosphorus and magnesium (colorimetric method).
Results:
Elevated serum PTHi levels were observed in 29% of the patients and hypocalcemia in 0.9% from the 3rd postoperative month and afterwards (3 to 80 months after surgery).
Conclusion:
There is a need for careful evaluation of bone metabolism and for routine calcium replacement after RYGBP.
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