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Protein kinase C increase in rat brain cortical membranes may be promoted by cognition enhancing drugs
S Govoni1, L Lucchi, F Battaini
1Pharmacobiology Dept., Univ. of Bari, Italy.
Life Sciences
|January 1, 1992
Abstract:
Protein Kinase C (PKC) activity was measured in soluble and particulate fractions of rat individual brain cortices after in vivo treatment with two cognition enhancers: oxiracetam and alpha-glicerylphosphorylcholine. Both drugs induced an increase (+40-50%) of PKC particulate activity at 1 hr after the treatment. The effect was transient; at 5 hours PKC activity was lower than in controls. The dose response curve to oxiracetam was bell shaped, the increase of PKC being significant at 100 mg/kg. At higher doses the drug induced a decrease in enzyme activity. The increased PKC activity may be related to the cortical effects of these compounds.