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Morphometrical analysis of the kidney from nonobese diabetic (NOD) mice in the non-diabetic stage

Michie Maeda1, Akira Yabuki, Mitsuharu Matsumoto

  • 1Department of Veterinary Anatomy, Faculty of Agriculture, Kagoshima University, Japan.

The Journal of Veterinary Medical Science
|November 6, 2004
PubMed

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Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...