Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Public defibrillation: increased survival from a structured response system.

Judy Powell1, Lois Van Ottingham, Eleanor Schron

  • 1Clinical Trial Center, University of Washington, Seattle, Wash., USA. jlpowell@u.washington.edu

The Journal of Cardiovascular Nursing
|November 6, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improving End of Life Cancer Outcomes Through Development and Implementation of a Spiritual Care Advocate Program.

The American journal of hospice & palliative care·2021
Same author

Self-report measures of medication adherence behavior: recommendations on optimal use.

Translational behavioral medicine·2015
Same author

Chest compression fraction: A time dependent variable of survival in shockable out-of-hospital cardiac arrest.

Resuscitation·2015
Same author

Regarding manuscript: "resuscitation outcomes consortium-amiodarone, lidocaine, or placebo study: rationale and methodology behind out-of-hospital cardiac arrest antiarrhythmic drug trial".

American heart journal·2014
Same author

Resuscitation Outcomes Consortium-Amiodarone, Lidocaine or Placebo Study (ROC-ALPS): Rationale and methodology behind an out-of-hospital cardiac arrest antiarrhythmic drug trial.

American heart journal·2014
Same author

The idiopathic intracranial hypertension treatment trial: design considerations and methods.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society·2014

Automated external defibrillators (AEDs) significantly improve survival rates for out-of-hospital cardiac arrest (OOH-CA) when used by trained lay responders. The PAD trial showed doubling survival to hospital discharge with CPR plus AED compared to CPR alone.

Area of Science:

  • Emergency Medicine
  • Public Health
  • Cardiovascular Research

Background:

  • Out-of-hospital cardiac arrest (OOH-CA) remains a leading cause of death.
  • Early defibrillation is critical for improving survival rates.
  • The Public Access Defibrillation (PAD) trial investigated layperson use of AEDs.

Purpose of the Study:

  • To compare survival to hospital discharge for OOH-CA.
  • To evaluate the effectiveness of CPR alone versus CPR plus automated external defibrillator (AED) by lay responders.
  • To assess the feasibility of implementing community-based AED programs.

Main Methods:

  • Prospective, randomized, controlled trial across 24 centers in the US and Canada.
  • Trained over 19,000 layperson responders in CPR-only or CPR+AED protocols.

Related Experiment Videos

  • 993 community units (1260 facilities) were randomized.

    • Main Results:

    • Survival to hospital discharge was doubled in the CPR+AED group compared to the CPR-only group (30% vs 15%, P = .03).
    • Relative Risk (RR) for survival was 2.0 (95% CI [1.07-3.77]) with CPR+AED.
    • Implementation required significant focus on infrastructure, training, and oversight.

    Conclusions:

    • Use of AEDs by trained nonmedical responders within a structured system significantly increases survival after OOH-CA.
    • Community-based AED programs can be effectively implemented.
    • AEDs are safe and effective when used by layperson responders.