Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The renal response to preeclampsia.

Paul Moran1, Marshall D Lindheimer, John M Davison

  • 1Department of Obstetrics and Gynecology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.

Seminars in Nephrology
|November 6, 2004
PubMed
Summary

Preeclampsia reduces kidney function by decreasing renal blood flow and glomerular filtration rate (GFR). A significant drop in the ultrafiltration coefficient (Kf) is the likely cause of reduced GFR and proteinuria.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mental health of healthcare workers in England during the first three years of the COVID-19 pandemic: The NHS CHECK study cohort.

PloS one·2026
Same author

Personality development from early to middle adulthood in the general population and those with mental health difficulties.

Scientific reports·2026
Same author

The Effects of Social Media on Adolescent Mental Health: Findings From a Population-Based Cohort Study in Australia.

The Medical journal of Australia·2026
Same author

Right aortic arch and double arch assessed by prenatal echocardiography: a population-based study.

European heart journal·2026
Same author

The longitudinal trajectories of mental health outcomes in healthcare workers in England during the COVID-19 pandemic.

Psychological medicine·2026
Same author

Investigating the Impact of Lived Experience Stories on Self-Harm, Mood, and Help-Seeking Intentions: Web-Based Between-Participants Experimental Study in Individuals With Recent Self-Harm.

JMIR human factors·2026

Area of Science:

  • Nephrology
  • Obstetrics
  • Pathophysiology

Background:

  • Preeclampsia is characterized by proteinuria and decreased renal function.
  • The kidney's structure and blood flow are crucial for understanding preeclampsia.
  • Renal hemodynamics and glomerular barrier integrity are key factors in preeclamptic disease.

Purpose of the Study:

  • To review characteristic renal structural changes in preeclampsia.
  • To focus on disordered renal hemodynamics and ultrafiltration determinants.
  • To elucidate the mechanisms behind decreased GFR and proteinuria in preeclampsia.

Main Methods:

  • Review of structural changes in preeclamptic kidneys.
  • Analysis of renal hemodynamics and ultrafiltration.
  • Examination of glomerular barrier integrity using fractional dextran clearance studies.

Main Results:

  • Renal blood flow and glomerular filtration rate (GFR) decrease in preeclampsia.
  • A ~50% reduction in the ultrafiltration coefficient (Kf) is the most probable cause of decreased GFR.
  • Proteinuria is linked to impaired glomerular barrier integrity and loss of size selectivity.

Conclusions:

  • Decreased GFR in preeclampsia is likely due to reduced Kf and/or renal blood flow.
  • Impaired glomerular barrier integrity contributes to proteinuria.
  • Further research is needed to confirm the loss of glomerular barrier charge selectivity in preeclampsia.

Related Experiment Videos