Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Catalytic antibodies].

D Baron1

  • 1Boehringer Mannheim GmbH, FRG.

Die Naturwissenschaften
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Catalytic antibodies (catabs) offer immense variability and potential applicability through diverse production methods. Despite challenges like low affinity and slow turnover, ongoing refinements enhance their utility in chemical synthesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hypovolemic shock due to massive subcutaneous hemorrhage in a patient with musculocontractural Ehlers-Danlos syndrome (mcEDS).

Wiener klinische Wochenschrift·2025
Same author

Reply to Letter to the Editor: 'A phase III randomised trial on the addition of a contact x-ray brachytherapy boost to standard neoadjuvant chemo-radiotherapy for organ preservation in early rectal adenocarcinoma: 5 years results of the OPERA trial' by J. Meyer, T. Koessler.

Annals of oncology : official journal of the European Society for Medical Oncology·2025
Same author

Prognostic Values of Pre- and Post-Therapeutic FDG-PET in Anal Canal Cancer: Analysis of a Prospective Study.

Clinical colorectal cancer·2025
Same author

A phase III randomised trial on the addition of a contact X-ray brachytherapy boost to standard neoadjuvant chemo-radiotherapy for organ preservation in early rectal adenocarcinoma: 5 year results of the OPERA trial.

Annals of oncology : official journal of the European Society for Medical Oncology·2024
Same author

'Folfirinox' chemotherapy combined with contact x-ray brachytherapy 50kVp and 'CAP50' chemoradiotherapy aiming at organ preservation for selected intermediate distal-middle cT2-T3 rectal cancers: A feasibility study.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2024
Same author

Response to "Stereotactic body radiotherapy for oligoprogressive lesions in metastatic castration-resistant prostate cancer patients - A closer inspection will improve your vision".

Clinical and translational radiation oncology·2024
Same journal

Could snort production reflect comfort in horses kept outdoors? A first study.

Die Naturwissenschaften·2026
Same journal

Pyrazole-thiazolidine hybrids as α-amylase inhibitor: a mechanistic and computational investigation.

Die Naturwissenschaften·2026
Same journal

Conventional methods may cause allometric analyses to be unreliable.

Die Naturwissenschaften·2026
Same journal

Impact of habitat disturbance on activity pattern and diet of de brraza's monkey (Cercopithecus neglectus) in kafa biosphere reserve, South West Ethiopia.

Die Naturwissenschaften·2026
Same journal

Ethnobotany of desert medicinal plants and their sustainable ethnomedicinal utilization.

Die Naturwissenschaften·2026
Same journal

Temperature effects on survival and dormancy patterns across age groups in vulnerable land snail Vertigo moulinsiana.

Die Naturwissenschaften·2026
See all related articles

Area of Science:

  • Biochemistry
  • Immunology
  • Synthetic Chemistry

Context:

  • Catalytic antibodies (catabs) are engineered proteins with enzymatic activity.
  • Current production involves monoclonal antibody generation, large-scale library screening, and catalytic motif transplantation.
  • Further optimization is achievable through chemical modification and in vitro mutagenesis.

Purpose:

  • To review current methods for producing catalytic antibodies.
  • To highlight the advantages and disadvantages of existing catalytic antibody technologies.
  • To discuss the potential for broader applications of catalytic antibodies.

Summary:

  • Three primary methods exist for generating catalytic antibodies: targeting transition states, screening large antibody libraries, and incorporating catalytic motifs.

Related Experiment Videos

  • Refinements via chemical modification and mutagenesis can improve catalytic antibody performance.
  • Key limitations include empirical production, low affinity, and slow reaction rates.

    • Impact:

    • Catalytic antibodies present significant variability in antigen-binding sites.
    • The conserved structure of antibody binding sites suggests broad applicability for this technology.
    • Advancements in catalytic antibody production could revolutionize biocatalysis and chemical synthesis.