Jove
Visualize
Contact Us

Related Experiment Videos

[Homozygous hemoglobin-E (Hb-EE) disease].

G Amendola1, P Danise, A Di Palma

  • 1Ematologia, Oncologia Pediatrica. gamendolaq@tin.it

La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics
|November 9, 2004
PubMed
Summary

Homozygous hemoglobin E (HbE) disease, common in Southeast Asians, was diagnosed in a Cambodian teen presenting with hematuria. This condition is typically benign but can be severe when combined with beta-thalassemia.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exercise pulmonary hypertension in asymptomatic patients with HIV infection Insights from the RIGHT-NET registry.

European journal of internal medicine·2026
Same author

Pesticides and trace elements in geophagic clay materials sourced in Cameroon and Nigeria: Potential implications on human health.

The Science of the total environment·2025
Same author

Processing factors of pesticide residues in durum wheat milling fractions and pasta.

Food chemistry·2025
Same author

Testing mosses exposed in bags as biointerceptors of airborne radiocaesium after the Fukushima Dai-ichi Nuclear Power Station accident.

Chemosphere·2022
Same author

Toxicological aspects of cannabinoid, pesticide and metal levels detected in light Cannabis inflorescences grown in Italy.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2021
Same author

PET/MRI for staging patients with Hodgkin lymphoma: equivalent results with PET/CT in a prospective trial.

Annals of hematology·2021
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Genetics
  • Hematology

Background:

  • Hemoglobin E (HbE) is a common variant in Southeast Asian populations.
  • Understanding HbE-related disorders is crucial due to global migration patterns.

Observation:

  • A 16-year-old Cambodian female presented with hematuria and mild microcytic, hypochromic anemia.
  • Hemoglobin electrophoresis revealed no HbA, increased HbF, and a band similar to HbA2.
  • DNA technology confirmed a diagnosis of homozygous hemoglobin E disease.

Findings:

  • Homozygous HbE disease is generally considered benign.
  • Co-inheritance of HbE with beta-thalassemia can result in a severe clinical presentation, comparable to homozygous beta-thalassemia.

Implications:

  • The increasing prevalence of HbE in Western countries presents a global health challenge.

Related Experiment Videos

  • Accurate diagnosis and management of HbE syndromes are critical for healthcare professionals caring for patients with thalassemia.