Synthesis, structure, and cooperative proton-electron transfer reaction of Bis(5,6-diethylpyrazinedithiolato)metal complexes (M = Ni, Pd, Pt)
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Updated: Aug 21, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Takashi Kubo1, Misako Ohashi, Katsuaki Miyazaki
1Department of Chemistry, Graduate School of Science, Osaka University, Machikaneyama 1-1, Toyonaka, Osaka 560-0043, Japan. kubo@chem.sci.osaka-u.ac.jp
Abstract:
New proton and electron donors, M(II)(HL)(2) (M = Ni, Pd, Pt; L = 5,6-diethylpyradzinedithiolate), as well as a proton and electron acceptor, Pt(IV)(L)(2), were prepared and characterized. The pH-dependent cyclic voltammetry of the M(II)(HL)(2) complexes revealed a favorable Gibbs free energy (K(com) > 1) for the proton and electron transfer reactions from M(II)(HL)(2) to M(IV)(L)(2); i.e., the equilibrium for the following reaction lies to the right: M(II)(HL)(2) + M(IV)(L)(2) <==>2M(III)(HL)(L).
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