Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Parkinson's disease without expected neuropathologic abnormality.

Miodrag Velickovic1, Gerson Lesser, Dushyant Purohit

  • 1Jewish Home & Hospital Lifecare System, New York, NY 10025, USA.

Journal of the American Medical Directors Association
|November 9, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-Nuclei Transcriptomic Characterization of <i>APOE4</i> -Associated Alzheimer's Disease.

bioRxiv : the preprint server for biology·2026
Same author

Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study.

Acta neuropathologica communications·2021
Same author

Progressive Multifocal Leukoencephalopathy in a Patient With Progressive Multiple Sclerosis Treated With Ocrelizumab Monotherapy.

JAMA neurology·2021
Same author

Molecular abnormalities in autopsied brain tissue from the inferior horn of the lateral ventricles of nonagenarians and Alzheimer disease patients.

BMC neurology·2020
Same author

Artificial intelligence in neuropathology: deep learning-based assessment of tauopathy.

Laboratory investigation; a journal of technical methods and pathology·2019
Same author

Major Need of Foreign Medical Graduate Physicians for Insights into Older Americans.

Journal of the American Geriatrics Society·2018
Same journal

Pilot Implementation of the Shed-MEDS Deprescribing Intervention for Persons With Dementia in Assisted Living Facilities.

Journal of the American Medical Directors Association·2026
Same journal

Disease-Related Factors Contributing to the Increase in the Frequency of Care Provided by Working Family Caregivers During the COVID-19 Pandemic: A Cross-Sectional Study.

Journal of the American Medical Directors Association·2026
Same journal

Frailty Trajectories in Men Aged 71 Years or Older Living in Western Australia: Results From the Health in Men Study.

Journal of the American Medical Directors Association·2026
Same journal

Resident- and Facility-Level Correlates of Resident-Reported Quality of Life in Assisted Living Facilities in Minnesota.

Journal of the American Medical Directors Association·2026
Same journal

The Embedded Model for Bridging Essential Delivery of Care in Assisted Living Facilities-EMBED-ALF.

Journal of the American Medical Directors Association·2026
Same journal

Opportunities for Improving End-of-Life Care for Veterans Receiving Hospice in Community Nursing Homes.

Journal of the American Medical Directors Association·2026
See all related articles

This case study presents a Parkinson's disease (PD) patient who showed classic symptoms and responded well to levodopa/carbidopa (LD/CD) treatment for 10 years. Autopsy revealed no typical PD brain changes, challenging current disease understanding.

Area of Science:

  • Neurology
  • Neuroscience
  • Pathology

Background:

  • Idiopathic Parkinson's disease (PD) is characterized by specific neuropathological hallmarks, including substantia nigra neuronal loss and Lewy bodies.
  • Levodopa/carbidopa (LD/CD) is a primary treatment for PD symptoms.
  • The potential neurotoxicity of LD/CD remains a subject of investigation.

Observation:

  • A 78-year-old male presented with classic idiopathic Parkinson's disease (PD) symptoms and a sustained positive response to levodopa/carbidopa (LD/CD) over a decade.
  • Neuropathological examination at autopsy revealed no loss of neurons in the substantia nigra.
  • Absence of Lewy bodies and alpha-synuclein pathology was confirmed in multiple brain regions.

Findings:

  • The case demonstrates typical Parkinson's disease (PD) clinical presentation and progression without the expected neuropathological correlates.

Related Experiment Videos

  • Substantia nigra cell count was within normal limits despite long-term LD/CD treatment, refuting the hypothesis of LD/CD-induced toxicity in this instance.
  • This finding challenges the direct link between specific neuropathology and clinical manifestation in some PD cases.

    • Implications:

    • Highlights the need for alternative explanations for Parkinson's disease (PD) symptoms beyond established neuropathological markers.
    • Suggests that the clinical diagnosis and treatment response in PD may not always align with traditional pathological findings.
    • Underscores the complexity of Parkinson's disease (PD) pathogenesis and the limitations of current diagnostic and etiological models.