Related Experiment Video
Updated: Aug 21, 2026

Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals
Published on: September 20, 2021
Facial cellulitis associated with Pseudomonas aeruginosa complicating ophthalmic herpes zoster
Laura Atzori1, Caterina Ferreli, Myriam Zucca
1Clinica Dermatologica, Universita di Cagliari, Italy. lauratzori@tin.it
Abstract:
Cellulitis is a rare and severe soft-tissue infection characterized by acute, diffuse, spreading inflammation, often associated with systemic symptoms such as malaise and fever. Surgery of the head and neck, dental infections, sinusitis, upper respiratory tract infections, and trauma are the most common portal of entry for pathogens in facial cellulitis. A very unusual case complicating an ophthalmic herpes zoster in a 74-year-old woman was observed at the department of dermatology, Cagliari University (Italy). Culture of skin swabs showed growth of numerous Gram-negative bacilli, further identified as Pseudomonas aeruginosa. Therapy with intravenous ciprofloxacin was promptly instituted on the basis of the culture and sensitivity report. She was initially treated with daily drainage and twice-daily topical fusidic acid. The lesion completely resolved in 4 weeks, and no general complications or recurrence have been observed for 6 months. Early recognition and management of facial cellulitis is mandatory to avoid serious and generalized complications. Pseudomonas aeruginosa is rarely reported in facial cellulitis; there are apparently no reports of this infection occurring as a complication of ophthalmic herpes zoster. Herpetic damage of the anatomic barrier as well as impairment of defense mechanisms because of decompensated diabetes mellitus may have facilitated the colonization and proliferation of this opportunistic pathogen in our patient.
Insights
This case study highlights a rare instance of facial cellulitis caused by Pseudomonas aeruginosa, a Gram-negative bacillus. This infection complicated ophthalmic herpes zoster in a diabetic patient, emphasizing the need for prompt recognition and management of such severe soft-tissue infections.
Area of Science:
- Dermatology
- Infectious Diseases
Background:
- Facial cellulitis is a severe soft-tissue infection with common entry points including head and neck surgery, dental infections, and trauma.
- Prompt recognition and management are crucial to prevent severe complications.
Observation:
- A 74-year-old woman with ophthalmic herpes zoster and diabetes developed facial cellulitis.
- Skin swabs revealed Pseudomonas aeruginosa, a Gram-negative bacillus, as the causative agent.
- Treatment involved intravenous ciprofloxacin, daily drainage, and topical fusidic acid.
Findings:
- The facial cellulitis caused by Pseudomonas aeruginosa completely resolved within 4 weeks.
- No general complications or recurrence were observed during a 6-month follow-up.
- This represents a rare occurrence of Pseudomonas aeruginosa in facial cellulitis, especially as a complication of ophthalmic herpes zoster.
Implications:
- Herpetic damage and impaired immune defense in diabetic patients may predispose to opportunistic infections like this.
- This case underscores the importance of considering unusual pathogens in facial cellulitis, particularly in immunocompromised individuals.
- Early diagnosis and appropriate antibiotic therapy are vital for successful outcomes in complex cellulitis cases.
Related Concept Videos
Chickenpox
Microbiome of the Eye
Genital Herpes
Herpes
Brain Abscess l: Introduction
Staphylococcal Skin Infections
