Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Novel insights into hepatitis C virus replication and persistence.

Ralf Bartenschlager1, Michael Frese, Thomas Pietschmann

  • 1Department of Molecular Virology, University of Heidelberg, Im Neuenheimer Feld 345, 69120 Heidelberg, Germany.

Advances in Virus Research
|November 9, 2004
PubMed
Summary

Hepatitis C virus (HCV) research advanced significantly with genome cloning and cell culture systems. These tools enable detailed studies of viral RNA replication and persistence, crucial for understanding chronic liver disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nanophase Goethite as a Promising Target in the Search for Past Life on Mars.

Astrobiology·2026
Same author

The hepatitis E virus capsid protein forms amyloid-like fibrils that sequester TANK-binding kinase 1 to dampen antiviral responses.

Cell reports·2026
Same author

Renewed momentum for HCV and HCC research.

Journal of hepatology·2026
Same author

ProTides for Antiviral Activity Beyond Liver Cells.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Correction: RBM39 shapes innate immunity by controlling expression of key factors of the interferon response.

Frontiers in immunology·2026
Same author

Identification of single nucleotide polymorphisms in sheep Mx genes: A premature stop codon abolishes Mx2 protein expression but did not affect fertility and early animal development.

PloS one·2026

Area of Science:

  • Virology
  • Hepatology
  • Molecular Biology

Background:

  • Hepatitis C virus (HCV) is an enveloped RNA virus causing persistent infections and chronic liver disease.
  • HCV research accelerated following its genome cloning in 1989.
  • An efficient cell culture system developed in 1999 facilitated in-depth molecular studies.

Purpose of the Study:

  • To summarize the current knowledge on Hepatitis C virus RNA replication.
  • To review the molecular mechanisms of HCV persistence.
  • To provide an overview of actively researched areas in HCV studies.

Main Methods:

  • Genomic organization delineation.
  • Viral protein characterization.
  • Intracellular HCV life cycle studies using cell culture systems.

Related Experiment Videos

Main Results:

  • Detailed understanding of HCV genomic structure.
  • Insights into viral protein functions.
  • Elucidation of viral RNA replication and persistence mechanisms in cell culture.

Conclusions:

  • Significant progress in understanding HCV molecular biology.
  • Cell culture systems are vital for studying viral RNA replication and persistence.
  • Ongoing research continues to advance knowledge on HCV pathogenesis and infection.