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MK-801 upregulates the expression of d-amino acid oxidase mRNA in rat brain
Masanobu Yoshikawa1, Tetsuo Oka, Mitsuru Kawaguchi
1Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa, 259-1143, Japan.
Brain Research. Molecular Brain Research
|November 9, 2004
Abstract:
We have evaluated the effect of the systemic administration of MK-801 (0.4 mg/kg) on the gene expression of D-amino acid oxidase (DAO) in several brain areas of the rat. The levels of DAO mRNA in all the brain areas significantly increased and peaked at 4 h after the administration. The present results suggest that there is a link between the expression of DAO mRNA and the N-methyl-D-aspartate (NMDA) receptor activity.
