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Updated: Aug 21, 2026

A Culture Method to Maintain Quiescent Human Hematopoietic Stem Cells
Published on: May 17, 2021
Diverse mechanisms regulate stem cell self-renewal
Anna V Molofsky1, Ricardo Pardal, Sean J Morrison
1Howard Hughes Medical Institute, and Department of Internal Medicine, University of Michigan, 1500 E. Medical Center Drive, 3215 CCGC, Ann Arbor, Michigan 48109-0934, USA.
Abstract:
To what extent are the pathways that regulate self-renewal conserved between stem cells at different stages of development and in different tissues? Some pathways play a strikingly conserved role in regulating the self-renewal of diverse stem cells, whereas other pathways are specific to stem cells in certain tissues or at certain stages of development. Recent studies have highlighted differences between the self-renewal of embryonic, fetal and adult stem cells. By understanding these similarities and differences we may come to a molecular understanding of how stem cells replicate themselves and why aspects of this process differ between stem cells.
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