Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A study of L-thyroxine replacement.

J R Burnett1, R Cooke, M J Crooke

  • 1Department of Endocrinology, Wellington Hospital.

The New Zealand Medical Journal
|March 25, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Purdue Pegboard test for surveillance of vibration-exposed workers.

Occupational medicine (Oxford, England)·2025
Same author

Cosmology and fundamental physics with the ELT-ANDES spectrograph.

Experimental astronomy·2024
Same author

Early-life gut bacterial community structure predicts disease risk and athletic performance in horses bred for racing.

Scientific reports·2024
Same author

COVID-19 associated with Raynaud's phenomenon in a vibration-exposed worker.

Occupational medicine (Oxford, England)·2023
Same author

Successful rehabilitation and release of a powerful owl chick with suspected rodenticide poisoning.

Australian veterinary journal·2023
Same author

Behavioural intervention to promote the uptake of planned care in urgent dental care attenders: study protocol for the RETURN randomised controlled trial.

Trials·2022
Same journal

Reed diffusers: a potential cause of poisoning in young children in New Zealand.

The New Zealand medical journal·2026
Same journal

Stuffy nights: elevated bedroom carbon dioxide concentrations indicate inadequate ventilation in Wellington homes.

The New Zealand medical journal·2026
Same journal

Cautionary tale of how sodium polystyrene sulfonate caused gut necrosis: a case report.

The New Zealand medical journal·2026
Same journal

Emergency lateral canthotomy and cantholysis for acute globe subluxation.

The New Zealand medical journal·2026
Same journal

Liberation of an incarcerated tibialis posterior tendon following a posterior malleolar ankle fracture: a case report.

The New Zealand medical journal·2026
Same journal

Implementing a cultural safety training plan across medical colleges in Aotearoa New Zealand-looking back, and looking forward.

The New Zealand medical journal·2026
See all related articles

Optimizing L-thyroxine (T4) dosage for primary hypothyroidism is crucial. Many patients have abnormal thyroid function tests, indicating a need for better treatment monitoring and dose adjustments for effective thyroid hormone replacement.

Area of Science:

  • Endocrinology
  • Pharmacology

Background:

  • Primary hypothyroidism requires L-thyroxine (T4) replacement therapy.
  • Monitoring treatment efficacy is essential for patient outcomes.

Purpose of the Study:

  • To assess the adequacy of L-thyroxine (T4) dosing in primary hypothyroidism patients.
  • To evaluate thyroid function test (TFT) results and T4 dose adjustments.

Main Methods:

  • Retrospective analysis of consecutive in vitro thyroid function tests.
  • Study included patients on L-thyroxine for primary hypothyroidism over three months.
  • Thyroid-stimulating hormone (TSH) and free T4 (fT4) levels were analyzed.

Main Results:

  • Normal serum sensitive TSH (sTSH) achieved in only 43-52% of patients, varying by physician type.

Related Experiment Videos

  • Elevated sTSH noted in 32-43%, suppressed sTSH in 15-17%.
  • Optimal T4 dose for normalization approximated 110 micrograms/day; dose adjustments were made in 30-36% of patients with abnormal sTSH.

    • Conclusions:

    • Current L-thyroxine (T4) dosing strategies frequently result in suboptimal thyroid function test (TFT) normalization.
    • Serum free T4 (fT4) is not a reliable screening test for T4 replacement adequacy.
    • Improved monitoring and dose titration are necessary for effective hypothyroidism management.