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Decrease in luteinizing hormone pulse frequency during a five-hour peripheral ghrelin infusion in the ovariectomized

Nicolas R Vulliémoz1, Ennian Xiao, Linna Xia-Zhang

  • 1Department of Obstetrics and Gynecology, College of Physicians & Surgeons, Columbia University, 630 West 168th Street, New York, New York 10032, USA.

The Journal of Clinical Endocrinology and Metabolism
|November 9, 2004
PubMed
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Ghrelin, a stomach hormone, was found to suppress reproductive hormone release in monkeys. This suggests ghrelin may explain why undernutrition, like anorexia nervosa, disrupts reproductive function.

Area of Science:

  • Neuroendocrinology
  • Reproductive Biology
  • Hormone Research

Background:

  • Ghrelin, a peptide hormone from the stomach, rises with food deprivation.
  • Undernutrition is linked to suppressed reproductive function.
  • The GnRH pulse generator's activity may be influenced by peripheral ghrelin levels.

Purpose of the Study:

  • To investigate the effect of elevated ghrelin on the reproductive axis.
  • To determine if ghrelin inhibits the GnRH pulse generator.

Main Methods:

  • Adult ovariectomized rhesus monkeys (n=6) received intravenous ghrelin or saline infusions.
  • Luteinizing hormone (LH) pulsatile release was monitored via blood sampling.
  • Plasma ghrelin levels were measured to confirm infusion efficacy.

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Main Results:

  • Ghrelin infusion increased plasma ghrelin levels by 2.9-fold.
  • Ghrelin significantly reduced LH pulse frequency (P < 0.05).
  • Cortisol and growth hormone (GH) release were stimulated by ghrelin; leptin was unaffected.

Conclusions:

  • Ghrelin inhibits GnRH pulse activity, potentially mediating reproductive suppression during undernutrition.
  • Ghrelin's role in conditions like anorexia nervosa is suggested.
  • Ghrelin stimulates the adrenal axis, though its link to GnRH inhibition requires further study.