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The MIPS mammalian protein-protein interaction database.

Philipp Pagel1, Stefan Kovac, Matthias Oesterheld

  • 1Institute for Bioinformatics/MIPS, GSF-National Research Center for Environment and Health, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.

Bioinformatics (Oxford, England)
|November 9, 2004
PubMed
Summary

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The MIPS mammalian protein-protein interaction database (MPPI) offers curated, high-quality interaction data for mammals. This resource is based on experimental evidence and accessible via download or a web interface.

Area of Science:

  • Biochemistry
  • Bioinformatics
  • Genomics

Background:

  • Protein-protein interactions (PPIs) are fundamental to cellular processes.
  • Mammalian PPIs are complex and crucial for understanding biological functions.
  • Existing databases may vary in data quality and curation rigor.

Purpose of the Study:

  • To introduce a new, high-quality database of mammalian protein-protein interactions.
  • To provide a reliable resource for researchers studying mammalian biology.
  • To facilitate the exploration and analysis of mammalian PPIs.

Main Methods:

  • Compilation of experimental protein interaction data from published literature.
  • Expert curation of interaction evidence by human curators.
  • Development of a comprehensive database and a user-friendly web interface.

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Main Results:

  • The MIPS mammalian protein-protein interaction database (MPPI) is established.
  • The database contains high-quality, experimentally validated mammalian PPI data.
  • The full dataset is available for download, alongside a flexible web interface.

Conclusions:

  • MPPI serves as a valuable new resource for mammalian protein interaction data.
  • The database ensures data quality through expert curation and experimental evidence.
  • MPPI supports diverse user needs with downloadable data and a powerful web interface.