Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Recurrent spontaneous miscarriages and hyperhomocysteinemia].

A Del Bianco1, G Maruotti, A M Fulgieri

  • 1Unità Operativa di Ginecologia e Ostetricia Universitaria, Università degli Studi di Foggia, Foggia.

Minerva Ginecologica
|November 9, 2004
PubMed
Summary

Elevated homocysteine levels are linked to recurrent pregnancy loss. Supplementing folic acid and vitamin B6 may improve outcomes for women with hyperhomocysteinemia.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Search for a Hidden Sector Scalar from Kaon Decay in the Dimuon Final State at ICARUS.

Physical review letters·2025
Same author

Nitrous oxide and hypnotherapy in paediatric dentistry.

European journal of paediatric dentistry·2023
Same author

Dim artificial light at night alters gene expression rhythms and growth in a key seagrass species (Posidonia oceanica).

Scientific reports·2023
Same author

ICARUS at the Fermilab Short-Baseline Neutrino program: initial operation.

The European physical journal. C, Particles and fields·2023
Same author

The connection between diverticulosis and colonic superficial neoplastic lesions in patients who underwent screening colonoscopy.

International journal of colorectal disease·2023
Same author

Exploring disease perception in Behçet's syndrome: combining a quantitative and a qualitative study based on a narrative medicine approach.

Orphanet journal of rare diseases·2023

Area of Science:

  • Obstetrics and Gynecology
  • Vascular Biology
  • Nutritional Science

Context:

  • Recurrent fetal loss, defined as at least two consecutive miscarriages before 16 weeks of gestation, is a significant pregnancy complication.
  • While thrombophilia is a known factor, vascular system damage and hyperhomocysteinemia are increasingly recognized as contributors to placental dysfunction and pregnancy loss.
  • Hyperhomocysteinemia, characterized by elevated homocysteine levels, is a risk factor for thrombotic diseases, independent of pregnancy.

Purpose:

  • To investigate the association between hyperhomocysteinemia and unexplained recurrent fetal loss.
  • To compare homocysteine levels in women with a history of recurrent fetal loss versus those with successful pregnancies.
  • To explore the potential role of homocysteine in placental vascular damage and subsequent pregnancy complications.

Related Experiment Videos

Summary:

  • A study of 40 patients with unexplained fetal loss and 40 controls revealed significantly different mean homocysteine levels (p ≤ 0.05).
  • Patients with recurrent fetal loss exhibited elevated plasma homocysteine levels (21±6 µmol/L) compared to controls (10±4 µmol/L).
  • High homocysteine levels were identified in 25% of women experiencing unexplained early fetal loss, suggesting a potential causative link.

Impact:

  • Hyperhomocysteinemia, potentially resulting from genetic factors and folate deficiency, may be a direct cause of recurrent miscarriages.
  • Screening for hyperhomocysteinemia is recommended in cases of unexplained recurrent fetal loss.
  • Treatment with folic acid and vitamin B6 offers a non-teratogenic approach to normalize homocysteine levels and improve pregnancy outcomes.