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Related Experiment Videos

[Chronic glomerulonephritis and pregnancy].

V A Rogov, E M Shilov, N L Kozlovskaia

    Terapevticheskii Arkhiv
    |November 10, 2004
    PubMed
    Summary

    Chronic glomerulonephritis (CGN) activity, hypertension, and renal failure increase risks for adverse pregnancy outcomes. While placental insufficiency worsens outcomes in CGN pregnancies, specific circulation and alpha-fetoprotein markers lack prognostic value.

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    [Morphological verification of renal lesion as a compulsory stage in the diagnosis of Fabry disease].

    Terapevticheskii arkhiv·2022

    Area of Science:

    • Nephrology
    • Obstetrics
    • Maternal-Fetal Medicine

    Context:

    • Chronic glomerulonephritis (CGN) presents unique challenges during pregnancy, impacting both maternal and fetal well-being.
    • Understanding risk factors is crucial for managing CGN pregnancies and improving outcomes.
    • Previous research has explored various maternal and fetal parameters, but prognostic indicators require further clarification.

    Purpose:

    • To identify risk factors for unfavorable pregnancy courses and outcomes in women with CGN.
    • To assess the prognostic significance of specific renal and uteroplacental indices in CGN pregnancies.

    Summary:

    • A study of 156 CGN patients analyzed pregnancy courses and outcomes, evaluating pre-pregnancy, during pregnancy, and post-delivery parameters.
    • Key findings include high rates of proteinuria, hypertension progression, renal function decline, fetal growth restriction, and preterm delivery.

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  • Placental insufficiency was evident, but Doppler indices and alpha-fetoprotein levels did not prove to be significant prognostic markers.

    • Impact:

    • Identifies critical risk factors such as CGN activity, hypertension, and renal failure for adverse pregnancy outcomes.
    • Highlights placental insufficiency as a significant contributor to poor outcomes in CGN pregnancies.
    • Clarifies that certain hemodynamic and biochemical markers are not reliable predictors of pregnancy complications in this cohort.