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Updated: Aug 21, 2026

Vessel-Sparing Microsurgical Longitudinal Intussusception Vasoepididymostomy to Treat Epididymal Obstructive Azoospermia
Published on: May 27, 2022
Evaluation and treatment of familial globozoospermia in five brothers
Zaid Kilani1, Radwan Ismail, Samer Ghunaim
1Farah Hospital, Amman, Jordan.
Objective:
To document the pathology of five siblings with complete globozoospermia and to report the effectiveness of repeated intracytoplasmic sperm injection (ICSI) treatment as therapy.
Design:
Case report.
Setting:
A tertiary center for assisted reproduction.
Patients(S):
Five siblings with globozoospermia.
Intervention(S):
Twenty cycles of repeated ICSI treatment. Detailed light and electron microscopy studies were performed on three of the globozoospermic brothers.
Main Outcome Measure(S):
Clinical pregnancy and live birth after ICSI treatment.
Result(S):
Light and electron microscopy showed that all spermatozoa had round heads and no acrosome. Of 129 metaphase-II oocytes injected, 49 fertilized normally, giving an overall fertilization rate of 38% (range, 0-100%). No pregnancies resulted from 13 cycles in brothers 1-3. Brothers 4 and 5 had three pregnancies after seven ICSI cycles, with one live birth and two first-trimester losses.
Conclusion(S):
Despite variable fertilization rates, pregnancies and a live birth can be achieved after repeated ICSI treatment cycles in globozoospermic siblings. No apparent pattern was manifest that reflected the true pathology or determined the outcome of ICSI treatment.
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