Related Experiment Video
Updated: Aug 11, 2026

Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
Pediatric middle ear infections and gastroesophageal reflux
P D Karkos1, D Assimakopoulos, W J Issing
1Department of Otolaryngology, The Freeman Hospital, Newcastle Upon Tyne, UK. pkarkos@aol.com
Insights
Gastroesophageal reflux (GER) may be linked to middle ear infections in children, but current evidence is insufficient to recommend anti-reflux treatments for persistent ear infections. More research is needed to confirm this connection.
Area of Science:
- Pediatric Otolaryngology
- Gastroenterology
Background:
- Middle ear infections (otitis media) in children have multiple causes, including anatomical, immunological, and environmental factors.
- Glue ear, a common consequence of otitis media, is the leading cause of childhood hearing loss.
- Gastroesophageal reflux (GER) is prevalent in infants and young children and may influence eustachian tube function.
Purpose of the Study:
- To review existing literature on the potential association between gastroesophageal reflux and otitis media in pediatric populations.
- To explore the possible mechanisms linking GER to eustachian tube dysfunction and middle ear infections.
Main Methods:
- A comprehensive literature review was conducted.
- The review focused on studies investigating the relationship between GER and otitis media in children.
Main Results:
- The current body of evidence is insufficient to establish a definitive causal link between GER and otitis media.
- Existing data do not support the routine use of antireflux interventions for children with recurrent or refractory middle ear infections.
Conclusions:
- Further high-quality research, including prospective randomized placebo-controlled trials, is necessary to clarify the role of GER in pediatric otitis media.
- The findings highlight the need for more robust evidence before implementing specific treatment strategies targeting GER for middle ear conditions.
Objectives:
The pathogenesis of middle ear infections in children is multifactorial and includes infection, anatomical factors, impaired immunologic status, allergy, familial predisposition, male sex, method of feeding and environmental factors. Glue ear remains the commonest cause of deafness in childhood. Gastroesophageal reflux (GOR) is a common problem in the newborn and preschool periods. Recent research suggests that it may be related to eustachian tube dysfunction and otitis media.
Methods:
We review the literature and discuss the possible relationship between Gastroesophageal reflux and otitis media in children.
Conclusions:
The current data are not enough to support antireflux treatment in children with refractory middle ear infections. More prospective randomised placebo-controlled studies are needed.
Related Concept Videos
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology
Gastroesophageal Reflux Disease II: Clinical Features and Management
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Esophageal Strictures-I: Introduction
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Esophageal Strictures-II: Clinical Features and Management
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Gastroesophageal Reflux Disease
Hiatal Hernia

