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Related Experiment Videos

Could inguinal hernia be treated medically?

John M Hutson1, Catherine Temelcos

  • 1F. Douglas Stephens Surgical Research Laboratory, Murdoch Children's Research Institute, Parkville, Vic. 3052, Australia. john.hutson@rch.org.au

Medical Hypotheses
|November 10, 2004
PubMed
Summary

Calcitonin gene-related peptide (CGRP) may promote the closure of inguinal hernias by fusing hernial surfaces. This suggests a potential future chemical treatment for inguinal hernias, a common congenital anomaly.

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Area of Science:

  • Pediatric Surgery
  • Developmental Biology
  • Molecular Medicine

Background:

  • Inguinal hernia is the most common congenital anomaly necessitating surgical intervention.
  • Persistence of the processus vaginalis is the primary cause of inguinal hernia.
  • The genitofemoral nerve and calcitonin gene-related peptide (CGRP) are implicated in testicular descent in rodents.

Purpose of the Study:

  • To investigate the potential role of CGRP in the closure of inguinal hernias.
  • To explore whether mechanisms regulating testicular descent also govern hernia closure.

Main Methods:

  • Hernial sacs from patients undergoing herniotomy were utilized.
  • The effect of CGRP and its analogs (CGRP 8-37, CGRP 27-37), as well as dihydrotestosterone, on hernial sac fusion was assessed.

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  • The impact of hepatocyte growth factor on peritoneal obliteration was evaluated in vitro.

    • Main Results:

    • CGRP significantly induced fusion of the hernial surfaces in vitro.
    • Inactive CGRP analogs and dihydrotestosterone did not promote fusion.
    • Hepatocyte growth factor also demonstrated the ability to cause peritoneal obliteration.

    Conclusions:

    • Obliteration of the processus vaginalis appears to be regulated by molecules originating from the genitofemoral nerve, including CGRP.
    • These findings suggest the theoretical possibility of developing a chemical treatment for inguinal hernias.