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Prognostic value of left ventricular concentric remodeling in uncomplicated mild hypertension

Sante D Pierdomenico1, Domenico Lapenna, Anna Bucci

  • 1Dipartimento di Medicina e Scienze dell'Invecchiamento, University Gabriele d'Annunzio, Chieti, Italy.

American Journal of Hypertension
|November 10, 2004
PubMed

Insights

Left ventricular (LV) concentric remodeling in mild hypertension patients indicates a worse cardiovascular outcome. This finding highlights the importance of assessing LV geometry for predicting cardiovascular events in hypertensive individuals.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Echocardiography

Background:

  • The prognostic significance of left ventricular (LV) concentric remodeling in essential hypertension, especially in mild, uncomplicated cases, remains unclear.
  • Previous studies have not fully elucidated the cardiovascular risks associated with LV concentric remodeling in this specific patient group.

Purpose of the Study:

  • To investigate the cardiovascular outcomes in patients with uncomplicated mild hypertension, comparing those with normal LV geometry to those with LV concentric remodeling.
  • To determine if LV concentric remodeling is an independent predictor of cardiovascular events in this population.

Main Methods:

  • A cohort of 1088 uncomplicated mild hypertensive patients was analyzed.
  • Patients were categorized into two groups: normal LV geometry (n=751) and LV concentric remodeling (n=337), based on LV mass index and relative wall thickness.
  • Fatal and nonfatal cardiovascular events were tracked over a mean follow-up of 4.74 years.

Main Results:

  • The event rate per 100 patient-years was significantly higher in patients with LV concentric remodeling (1.87) compared to those with normal LV geometry (0.69).
  • Cox regression analysis, adjusted for covariates, identified LV concentric remodeling as an independent predictor of cardiovascular events (RR 1.78, 95% CI 1.02 to 3.1, P < .05).

Conclusions:

  • LV concentric remodeling is associated with a worse cardiovascular prognosis in patients with uncomplicated mild hypertension.
  • Assessing LV geometry, specifically identifying concentric remodeling, is crucial for risk stratification in mild hypertensive patients.
Abstract

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