Related Experiment Video
Updated: Aug 21, 2026

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
Published on: September 26, 2018
Beyond hypertension toward guidelines for cardiovascular risk reduction
Massimo Volpe1, Michael H Alderman, Curt D Furberg
1Department of Cardiology, II Faculty of Medicine, University of Rome La Sapienza Rome, Rome, Italy. volpema@uniroma1.it
Insights
Current cardiovascular guidelines focus on single risk factors. A global cardiovascular risk assessment approach is proposed for more accurate patient treatment decisions, improving risk management strategies.
Area of Science:
- Cardiology
- Preventive Medicine
- Clinical Risk Assessment
Background:
- Current clinical guidelines predominantly manage individual cardiovascular risk factors like hypertension, hypercholesterolemia, and diabetes.
- A comprehensive evaluation of a patient's overall risk profile is crucial for effective cardiovascular disease risk reduction.
- Global risk assessment provides a more appropriate clinical approach to stratify individual patient risk.
Purpose of the Study:
- To demonstrate the implications of shifting from a single risk factor-based approach to a global risk assessment model for hypertension management.
- To advocate for the use of global cardiovascular risk as the primary determinant for treatment decisions in clinical practice and guidelines.
Main Methods:
- Utilized case studies to illustrate the impact of replacing traditional single risk factor management with global risk assessment.
- Compared treatment recommendations based on isolated blood pressure levels versus comprehensive risk profiles.
Main Results:
- Case studies showed that treatment decisions vary significantly when considering the entire risk profile, not just individual factors.
- Patients with mildly elevated blood pressure may not require antihypertensive drug treatment under a global risk assessment model, while others with lower blood pressure might.
Conclusions:
- Propose replacing the single risk factor-based approach with global cardiovascular risk assessment in clinical management.
- Advocate for integrating global risk assessment into clinical practice and future guidelines for improved cardiovascular disease prevention.
Background:
Most current clinical guidelines focus primarily on the management of individual cardiovascular risk factors, such as high blood pressure (BP), hypercholesterolemia, or diabetes. A more appropriate clinical approach to reducing cardiovascular disease risk would be based on a comprehensive evaluation of risk profile, and accurate stratification of global (absolute) risk in individual patients. We propose that global risk should be used as the main determinant of whom to treat, how to treat, and how much to treat.
Methods:
In this article we use a series of case studies to demonstrate the implications of replacing the traditional "single risk factor-based" approach to managing hypertension by one based on global risk assessment. In some situations patients with mildly elevated BP levels would not be recommended for antihypertensive drug treatment whereas others with lower BP would be treated, depending upon the entire risk profile.
Conclusion:
We propose to replace the single risk factor-based approach with the assessment of global cardiovascular risk, both in the clinical management of individual patients and in guidelines.
Related Concept Videos
Hypertension IV: Drug Therapy and Lifestyle Modifications
Atherosclerosis III: Management
Hypertension V: Nursing Management
Coronary Artery Disease IV: Preventive Measures
Hypertension II: Pathophysiology
Hypertension I: Introduction