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Intravitreal voriconazole: an electroretinographic and histopathologic study
Hua Gao1, Mark E Pennesi, Kekul Shah
1Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, TX, USA.
Archives of Ophthalmology (Chicago, Ill. : 1960)
|November 10, 2004
Summary
Intravitreal voriconazole up to 25 microg/mL is safe for rat retinas, showing no toxicity. This finding supports its potential use in treating fungal endophthalmitis.
Area of Science:
- Ophthalmology
- Mycology
- Toxicology
Context:
- Fungal endophthalmitis is a serious ocular infection.
- Voriconazole is a potent antifungal agent with broad-spectrum activity.
- Intravitreal administration of antifungal agents is a potential treatment strategy.
Purpose:
- To evaluate the retinal toxicity of intravitreal voriconazole in a rodent model.
- To determine the safety of voriconazole for intravitreal injection in treating fungal endophthalmitis.
Summary:
- Voriconazole was injected intravitreally into rats at concentrations ranging from 5 to 500 microg/mL.
- Electroretinography and histologic examination were performed to assess retinal toxicity.
- No significant electroretinographic changes or histologic abnormalities were observed at concentrations up to 25 microg/mL.
Impact:
- Intravitreal voriconazole at 25 microg/mL is safe in rat retinas.
- This study supports the potential use of intravitreal voriconazole for fungal endophthalmitis treatment.
- Further studies are warranted to confirm safety and efficacy in humans.