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Updated: Aug 21, 2026

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue
Published on: October 26, 2014
Paroxysmal alien limb phenomena due to epileptic seizures and electrical cortical stimulation
1Department of Presurgical Evaluation, Epilepsy Center Bethel, Bielefeld, Germany.
Abstract:
Alien limb phenomena (ALPs) are characterized by limb movements, which are subjectively experienced as involuntary or alien induced. ALPs regularly remain unchanged and occur as a consequence of frontal, callosal, or posterior cerebral lesions. The authors present two patients with paroxysmal ALP proved to be focal seizures by using video-EEG monitoring. In another two patients, ALP could experimentally be induced by electrical cortical stimulation. Based on the stimulation results, the authors suspect a functional disconnection of 1) sensory cortical areas providing information about the extrapersonal space; and 2) areas of the frontal and/or limbic cortex that are regularly involved in the processing and executing of intentional motor activity as a pathophysiologic substrate for ictal ALP.
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