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Updated: Aug 21, 2026

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
Published on: November 16, 2011
Peroxisome proliferator activated receptor ligands for the treatment of insulin resistance
David Patsouris1, Michael Müller, Sander Kersten
1Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, PO Box 8129, 6700 EV Wageningen, The Netherlands.
Abstract:
Peroxisome proliferator activated receptors (PPARs) are a group of ligand-activated transcription factors that play critical roles in the regulation of energy metabolism. Synthetic agonists for these receptors are used in the treatment of type 2 diabetes mellitus and dyslipidemia. Current data linking PPAR and/or PPAR ligands with the treatment of insulin resistance will be critically reviewed, with the focus on important advances over the past year.
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