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Optical analysis of synaptic vesicle recycling at the frog neuromuscular junction

W J Betz1, G S Bewick

  • 1Department of Physiology, University of Colorado School of Medicine, Denver 80262.

Science (New York, N.Y.)
|January 10, 1992
PubMed

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Fusion of Secretory Vesicles with the Plasma Membrane01:26

Fusion of Secretory Vesicles with the Plasma Membrane

Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...