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Enantioselective formal hydration of alpha,beta-unsaturated imides by Al-catalyzed conjugate addition of oxime

Christopher D Vanderwal1, Eric N Jacobsen

  • 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

Journal of the American Chemical Society
|November 13, 2004
PubMed
Summary

This study introduces an efficient catalytic method for asymmetric conjugate addition using salicylaldoxime, enabling enantioselective hydration of olefins. This breakthrough offers a novel route for synthesizing complex molecules, including polyketide natural products.

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