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Updated: Aug 21, 2026

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics
Published on: June 17, 2012
Sparse graphical Gaussian modeling of the isoprenoid gene network in Arabidopsis thaliana
Anja Wille1, Philip Zimmermann, Eva Vranová
1Reverse Engineering Group, Swiss Federal Institute of Technology (ETH), Zurich. awille@inf.ethz.ch
Abstract:
We present a novel graphical Gaussian modeling approach for reverse engineering of genetic regulatory networks with many genes and few observations. When applying our approach to infer a gene network for isoprenoid biosynthesis in Arabidopsis thaliana, we detect modules of closely connected genes and candidate genes for possible cross-talk between the isoprenoid pathways. Genes of downstream pathways also fit well into the network. We evaluate our approach in a simulation study and using the yeast galactose network.
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