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Updated: Aug 21, 2026

Phosphopeptide Analysis of Rodent Epididymal Spermatozoa
Published on: December 30, 2014
Role of tyrosine phosphorylation in sperm capacitation / acrosome reaction
Rajesh K Naz1, Preeti B Rajesh
1Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo, Ohio, USA. Rnaz@mco.edu
Abstract:
Capacitation is an important physiological pre-requisite before the sperm cell can acrosome react and fertilize the oocyte. Recent reports from several laboratories have amply documented that the protein phosphorylation especially at tyrosine residues is one of the most important events that occur during capacitation. In this article, we have reviewed the data from our and other laboratories, and have constructed a heuristic model for the mechanisms and molecules involved in capacitation/acrosome reaction.
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