Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cross-reactivity00:42

Cross-reactivity

28.8K
Overview
28.8K
Allergic Reactions02:06

Allergic Reactions

26.7K
Overview
26.7K
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.6K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.6K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.5K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.5K
Hypersensitivities01:30

Hypersensitivities

7.3K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
7.3K
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

293
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
293

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pharmacokinetics and pharmacodynamics of AQST-109 sublingual film in oral allergy syndrome: A phase 2 study.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same author

Low risk of ocular toxicity following topical ocular administration of epinephrine nasal spray: implications for unintentional exposure.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology·2026
Same author

Biologics and Novel Therapeutics in Food Allergy.

The journal of allergy and clinical immunology. In practice·2026
Same author

Navigating Oral Food Challenges in Clinical Trials to Keep the Science Moving Forward.

Allergy·2026
Same author

Pharmacokinetics and Pharmacodynamics Following Repeat Dosing of neffy (Epinephrine Nasal Spray) Versus Intramuscular Injection During Induced Allergic Rhinitis.

The journal of allergy and clinical immunology. In practice·2026
Same author

Service user perspectives on the value and effectiveness of occupational therapy following intervention for severe depression.

The British journal of occupational therapy·2026

Related Experiment Video

Updated: May 5, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

9.1K

Peanut allergy: recurrence and its management.

David M Fleischer1, Mary Kay Conover-Walker, Lynn Christie

  • 1Department of Pediatrics, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA.

The Journal of Allergy and Clinical Immunology
|November 13, 2004
PubMed
Summary

Children who outgrow peanut allergy face recurrence risk, especially if they avoid peanuts. Frequent peanut consumption is recommended to maintain tolerance and prevent allergy relapse.

More Related Videos

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

11.3K
Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

10.0K

Related Experiment Videos

Last Updated: May 5, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

9.1K
Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

11.3K
Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

10.0K

Area of Science:

  • Allergy and Immunology
  • Pediatric Allergy
  • Clinical Nutrition

Background:

  • Peanut allergy recurrence is possible, but its frequency is not well-established.
  • Understanding recurrence is crucial for managing patients with resolved peanut allergy.

Purpose of the Study:

  • Determine the recurrence rate of peanut allergy in children who initially outgrew it.
  • Identify risk factors associated with peanut allergy recurrence.
  • Develop evidence-based recommendations for managing resolved peanut allergy.

Main Methods:

  • Evaluated children with resolved peanut allergy using questionnaires, skin tests, and peanut-specific IgE levels.
  • Utilized double-blind, placebo-controlled food challenges (DBPCFC) to confirm tolerance or recurrence.
  • Assessed recurrence risk based on dietary peanut intake frequency.

Main Results:

  • The overall peanut allergy recurrence rate was 7.9%.
  • Patients consuming peanut products infrequently had a significantly higher recurrence rate compared to those consuming them frequently (P = .025).
  • Frequent peanut consumption was associated with sustained tolerance.

Conclusions:

  • Children who outgrow peanut allergy are at risk of recurrence.
  • Continued avoidance of peanuts after initial resolution increases recurrence risk.
  • Recommend frequent peanut ingestion and carrying epinephrine indefinitely for patients with resolved peanut allergy until ongoing tolerance is confirmed.