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An osteoporosis screening tool for Chinese men.
H S Lynn1, E M C Lau, S Y S Wong
1The School of Public Health, The Chinese University of Hong Kong, Hong Kong, China. hslynn@cuhk.edu.hk
Summary
A new Male Osteoporosis Screening Tool (MOST) effectively identifies Chinese men at risk for osteoporosis. This tool helps prioritize bone densitometry (DXA) scans, improving resource allocation and potentially reducing costs.
Area of Science:
- Gerontology
- Medical Diagnostics
- Public Health
Background:
- Osteoporosis screening tools are available for women, but not for men.
- Validated instruments are needed to identify men requiring bone densitometry (DXA).
Purpose of the Study:
- To develop and validate a Male Osteoporosis Screening Tool (MOST) for Chinese men aged 65 and above.
- To identify key risk factors for osteoporosis in this demographic.
Main Methods:
- Recruited 2,000 ambulatory Chinese men (aged 65+) in Hong Kong.
- Utilized dual-energy X-ray absorptiometry (DXA) for bone density measurements.
- Employed logistic regression and ROC analysis on a training sample (60%) to develop MOST, validating on the remaining 40%.
Main Results:
- Body weight and quantitative ultrasound index (QUI) were significant predictors.
- The MOST achieved an Area Under the Curve (AUC) of 0.823 (training) and 0.839 (validation).
- A cutoff score of 3 yielded 94% sensitivity and 46% specificity, with a 97.5% negative predictive value.
Conclusions:
- The MOST is a valuable tool for screening osteoporosis risk in Chinese men.
- It can help prioritize DXA screening, potentially saving resources.
- MOST complements DXA, aiding in efficient allocation for men at higher risk.