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Updated: Aug 21, 2026

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
Published on: June 2, 2015
The diagnostic evaluation of deep vein thrombosis
Simon J McRae1, Jeffrey S Ginsberg
1Department of Medicine, McMaster University, Hamilton, Ontario, Canada. smcrae@mcmaster.ca
Insights
Accurate diagnosis of deep vein thrombosis (DVT) is crucial. Noninvasive strategies, combining clinical assessment, ultrasound, and D-dimer tests, help manage DVT effectively, though optimal methods vary by institution.
Area of Science:
- Medical Diagnostics
- Vascular Medicine
- Thromboembolic Disease
Background:
- Venous thromboembolism (VTE) diagnosis is critical due to associated morbidity and mortality.
- Conventional venography for deep vein thrombosis (DVT) is invasive and expensive.
- Development of noninvasive diagnostic strategies is essential for efficient DVT management.
Purpose of the Study:
- To review noninvasive diagnostic strategies for deep vein thrombosis (DVT).
- To evaluate the combination of noninvasive tests for DVT diagnosis.
- To discuss the role of magnetic resonance venography in DVT assessment.
Main Methods:
- Review of diagnostic algorithms for DVT.
- Analysis of combined noninvasive testing strategies.
- Evaluation of clinical assessment, venous ultrasonography, and D-dimer testing.
- Consideration of magnetic resonance venography.
Main Results:
- Noninvasive tests often require combination to accurately assess DVT probability.
- Validated diagnostic algorithms incorporate clinical assessment, venous ultrasonography, and D-dimer testing.
- Optimal diagnostic strategies are institution-dependent, influenced by local expertise and cost.
Conclusions:
- Accurate and efficient DVT diagnosis is essential for patient outcomes.
- Combined noninvasive testing strategies are effective in DVT diagnosis and management.
- Magnetic resonance venography shows potential as a standalone DVT test but needs further research.
Abstract:
Due to the morbidity and mortality associated with either untreated disease or inappropriate anticoagulant therapy, accurate diagnosis of venous thromboembolism is essential. As venography, the current gold standard test for deep vein thrombosis (DVT), is both invasive and costly, noninvasive diagnostic strategies for diagnosing DVT have been developed. Noninvasive tests often have to be combined to either raise the post-test probability of disease to a level justifying treatment or lower it to a level at which withholding treatment is warranted. Diagnostic algorithms involving clinical assessment, venous ultrasonography, and D-dimer testing have been validated in management trials of patients with DVT. The optimal strategy at individual institutions is dependent on local expertise and cost. Magnetic resonance venography has the potential to be used as a stand-alone test for DVT but requires further evaluation.
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