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Related Experiment Videos

Haloperidol half-life after chronic dosing.

Jose de Leon1, Francisco J Diaz, Peter Wedlund

  • 1Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA. jdeleon@uky.edu

Journal of Clinical Psychopharmacology
|November 13, 2004
PubMed
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Haloperidol

Area of Science:

  • Pharmacokinetics
  • Clinical Pharmacology
  • Drug Metabolism

Background:

  • Haloperidol half-life varies significantly after chronic use.
  • Factors influencing this variability require further investigation.

Purpose of the Study:

  • To identify factors affecting haloperidol half-life in patients on chronic therapy.
  • Investigate the impact of gender, age, weight, race, genetics, comedication, and smoking.

Main Methods:

  • 31 patients received chronic haloperidol, followed by washout.
  • Plasma haloperidol levels were monitored for 2 months post-discontinuation.
  • Analysis included demographic, genetic (CYP2D6, CYP3A5), and lifestyle factors.

Main Results:

Related Experiment Videos

  • Mean haloperidol half-life was 3.9 days; detectable levels lasted 13.8 days.
  • 42% of patients had half-lives of 3 days or longer.
  • African-Americans and CYP2D6 poor metabolizers showed longer half-lives.
  • Haloperidol decanoate use was associated with prolonged half-lives.

    • Conclusions:

    • Chronic haloperidol administration leads to significantly longer half-lives than acute doses.
    • Race (African-American) and CYP2D6 genotype are potential determinants of prolonged haloperidol half-life.
    • Further research is needed to elucidate mechanisms of prolonged haloperidol elimination.