Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The E2F family: specific functions and overlapping interests.

Claire Attwooll1, Eros Lazzerini Denchi, Kristian Helin

  • 1Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.

The EMBO Journal
|November 13, 2004
PubMed
Summary

E2F transcription factors regulate cell cycle progression. This review summarizes recent advances in understanding E2F family functions and specificity, highlighting key questions in the field.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SMARCAL1 is a candidate therapeutic target for ALT-positive tumors.

Genes & development·2026
Same author

Epigenetic and oncogenic inhibitors converge to drive a metabolic catastrophe in castration-resistant prostate cancer.

The Journal of clinical investigation·2026
Same author

Nonsense-mediated mRNA decay safeguards telomeres in pluripotent stem cells.

Nature cell biology·2026
Same author

Acetylation of H3K115 is associated with fragile nucleosomes at CpG island promoters and active regulatory sites.

eLife·2026
Same author

SMARCAL1 is a candidate therapeutic target for ALT-positive tumors.

bioRxiv : the preprint server for biology·2026
Same author

Telomeres and Telomerase.

Cold Spring Harbor perspectives in biology·2026

Area of Science:

  • Molecular Biology
  • Cell Biology

Background:

  • E2F transcription factors are crucial regulators of cell cycle progression.
  • The study of E2F has advanced significantly since 1986.
  • Despite progress, new questions regarding E2F family functions emerge.

Purpose of the Study:

  • To review recent advancements in the E2F field.
  • To discuss unresolved key questions concerning E2F family.
  • To focus on the mechanisms of specificity among E2Fs.

Main Methods:

  • Literature review of recent studies on E2F transcription factors.
  • Analysis of current research on cell cycle regulation by E2F.
  • Synthesis of findings to address specificity mechanisms.

Main Results:

Related Experiment Videos

  • Recent progress has deepened the understanding of E2F roles.
  • Specificity among E2F proteins is a complex regulatory mechanism.
  • Several key questions regarding E2F regulation remain.

Conclusions:

  • The E2F field continues to evolve with ongoing research.
  • Understanding E2F specificity is critical for cell cycle control.
  • Further investigation is needed to fully elucidate E2F functions.