Related Experiment Video
Updated: Aug 21, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
Maternal infection and risk of cerebral palsy in term and preterm infants
Michael D Neufeld1, Chantal Frigon, Alan S Graham
1Department of Pediatrics (M.D.N.), Division of Neonatology, University of Washington, Seattle, WA 98195-6320, USA.
Objective:
We tested the hypothesis that term and preterm infants exposed to maternal infection at the time of delivery are at increased risk of developing cerebral palsy (CP).
Study Design:
A population-based case-control study was conducted using Washington State birth certificate data linked to hospital discharge data. Cases (688) were children
Results:
Infants of women who had any infection during their hospitalization for delivery were at increased risk of CP (odds ratio (OR) 3.1, 95% confidence interval (CI) 2.3 to 4.2). This was observed for term deliveries (OR 1.8, 95% CI 1.1 to 2.8) and preterm deliveries (OR 2.3, 95% CI 1.3 to 4.2).
Conclusions:
Our results suggest that maternal infection is a risk factor for CP in both term and preterm infants.
More Related Videos
08:50A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
07:13Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)
Published on: March 25, 2016
Related Concept Videos
Development of the Oral Microbiota
Malaria
Bacterial Meningitis II: Pathophysiology
Bacterial Meningitis I: Introduction
Teratogenicity
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...