Behavioral profile of SB 269970, a selective 5-HT(7) serotonin receptor antagonist, in social encounters between male...

The 5-HT(7) receptor is targeted by several antipsychotics, such as pimozide or clozapine, which have demonstrated antiaggressive properties in laboratory animal models. Likewise, 'in situ' hybridization and autoradiography studies have revealed moderate to high densities of 5-HT(7) receptors in limbic areas and hypothalamus, which have long been involved in the control of aggression. However, to date there is no evidence concerning the role of this receptor in the regulation of aggression. This study was designed to examine the effects of SB 269970 (1, 2, 4, 8, 16 and 32 mg/kg, i.p.), a selective 5-HT(7) receptor antagonist, on agonistic behavior elicited by isolation in mice. Individually housed mice were exposed to anosmic standard opponents 15 min after drug administration and encounters were videotaped and evaluated using an ethopharmacologically-based analysis. The results indicated that SB 269970 did not produce any significant behavioral changes, suggesting that 5-HT(7) receptors might not be involved in the modulation of aggression. Further studies with other selective ligands for these receptors are needed to confirm these findings.