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Related Experiment Videos

Renal ACE2 expression in human kidney disease.

A T Lely1, I Hamming, H van Goor

  • 1Department of Nephrology, Groningen University Medical Centre, Hanzeplein 1, 9713 GZ Groningen, The Netherlands. a.t.lely@nt.azg.nl

The Journal of Pathology
|November 13, 2004
PubMed
Summary

Angiotensin-converting enzyme 2 (ACE2) expression increases in kidney disease and transplants. This neo-expression in glomerular and peritubular capillary endothelium may indicate protective mechanisms in renal disorders.

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Area of Science:

  • Nephrology
  • Cardiovascular Research
  • Molecular Biology

Background:

  • Angiotensin-converting enzyme 2 (ACE2) counterbalances ACE activity.
  • ACE2 metabolizes angiotensin peptides, producing vasodilatory angiotensin (1-7).
  • ACE2 presence in human kidneys is known, but its role in renal disease is uncharacterized.

Purpose of the Study:

  • To investigate ACE2 expression in various human renal diseases and transplants.
  • To determine if ACE2 expression differs across renal pathologies.
  • To assess the impact of ACE inhibitor treatment on renal ACE2 expression.

Main Methods:

  • Immunohistochemical analysis of ACE2 expression in 58 renal disease biopsies, 17 renal transplants, and 18 normal kidney samples.
  • Semi-quantitative scoring of ACE2 staining.

Related Experiment Videos

  • Comparison of ACE2 expression between disease groups, transplants, and controls.
  • Evaluation of ACE inhibitor treatment effects.

    • Main Results:

    • ACE2 was detected in tubular and glomerular epithelium, and vascular cells in normal kidneys.
    • Neo-expression of ACE2 was observed in glomerular and peritubular capillary endothelium in all studied renal diseases and transplants.
    • No significant differences in ACE2 expression were found among different renal disorders or transplant conditions.
    • ACE inhibitor treatment did not affect ACE2 expression.

    Conclusions:

    • De novo expression of ACE2 occurs in the endothelium of glomerular and peritubular capillaries in primary and secondary renal diseases, and in transplanted kidneys.
    • The functional significance and potential protective role of this ACE2 neo-expression warrant further investigation.
    • ACE2 may play a role in the pathophysiology or adaptation to renal injury.