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Related Experiment Videos

[Invasive maxilar sinusitis by Rhizopus oryzae].

S Perea1, A del Palacio, R Gil

  • 1Servicio de Microbiología, Hospital Universitario 12 de Octubre, Madrid, España.

Revista Iberoamericana De Micologia
|November 13, 2004
PubMed
Summary

A diabetic patient with non-Hodgkin lymphoma developed invasive fungal sinusitis due to Rhizopus oryzae after steroid treatment. Despite aggressive treatment, the outcome was fatal, highlighting the severe risks of fungal infections in immunocompromised individuals.

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Area of Science:

  • Mycology
  • Infectious Diseases
  • Oncology

Context:

  • Diabetes mellitus and non-Hodgkin lymphoma are significant comorbidities.
  • Steroid immunosuppression is a common treatment modality with potential side effects.
  • Invasive fungal sinusitis is a rare but aggressive complication.

Purpose:

  • To report a case of invasive fungal sinusitis caused by Rhizopus oryzae in a diabetic patient with non-Hodgkin lymphoma.
  • To highlight the diagnostic challenges and clinical presentation of this rare fungal infection.
  • To discuss the treatment outcomes and associated mortality.

Summary:

  • A diabetic patient with non-Hodgkin lymphoma, treated with steroids, presented with severe facial pain and a necrotic nasal lesion.
  • Microscopic examination revealed broad, non-septate hyphae, and cultures isolated Rhizopus oryzae.

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  • Despite treatment with liposomal Amphotericin B and surgery, the patient experienced an unfavorable outcome and died.

    • Impact:

    • This case underscores the critical need for early diagnosis and aggressive management of invasive fungal sinusitis in immunocompromised patients.
    • It emphasizes the potential severity of Rhizopus infections, particularly in patients with diabetes and hematologic malignancies.
    • The case highlights the limitations of current treatment strategies and the importance of considering fungal etiologies in refractory sinusitis.