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Posaconazole therapy for severe abdominal candidiasis: a case report
Angela M Tobón1, Ana L Correa, Myrtha Arango
1Grupo de Micología Médica y Experimental, Corporación para Investigaciones Biológicas (CIB), Medellín, Colombia.
Revista Iberoamericana De Micologia
|November 13, 2004
Summary
Posaconazole successfully treated a fluconazole-resistant intra-abdominal Candida infection in a patient. This highlights posaconazole as a potential treatment for difficult-to-treat Candida infections.
Area of Science:
- Mycology
- Infectious Diseases
- Pharmacology
Background:
- Intra-abdominal Candida infections pose a significant clinical challenge.
- Fluconazole resistance in Candida species complicates treatment options.
Observation:
- A 68-year-old woman developed a fluconazole-resistant intra-abdominal infection.
- The infection involved Candida albicans and Candida tropicalis.
Findings:
- Successful treatment was achieved using posaconazole (SCH56592).
- Posaconazole demonstrated efficacy against fluconazole-resistant strains.
Implications:
- Posaconazole represents a viable therapeutic option for refractory Candida infections.
- This case underscores the importance of susceptibility testing for guiding antifungal therapy.