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Updated: Aug 21, 2026
Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
Published on: July 10, 2012
Donor-recipient gender mismatch in lung transplantation: impact on obliterative bronchiolitis and survival
David H Roberts1, John C Wain, Yuchiao Chang
1Pulmonary and Critical Care Unit, General Medical Services, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.
Background:
Because of the shortage of donor lungs, liberalization of donor selection criteria in terms of age, gas exchange, and smoking history has been proposed.
Methods:
We evaluated a single-institution population of lung transplant recipients (n = 98) for donor-recipient gender matching. We measured overall survival, time to acute allograft rejection, and time to development of obliterative bronchiolitis (OB).
Results:
We found significant improvement in overall survival for gender-mismatched donor and recipient pairs (p = 0.078) and a significantly shorter OB-free period for male donor and female recipient pairs (p = 0.017).
Conclusion:
These findings suggest that donor organ allocation based on gender may affect long-term survival and other outcomes after lung transplantation.
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